This work presents the persecution of some of the Church's Fathers, who, by with the combination of social political and religious circumstances, have been found to be the object of human badness and injustice. The exposition moves from being human as a being composed of the soul and body, whose components will lead to the original problem, and it is the relationship between good and evil. The biblical understanding of man's persecution will only light up for a moment through the struggle of Satan, the evil forces, and God, which will finally serve to illuminate the ultimate goal of this work. The legal and social structure of the Roman Empire shows that it is not friendly to a Christian man. In support of such a structure goes also pagan's poetry, and against the message of the Gospel. Therefore as a conclusion, the work brings a setting at the center of Jesus Christ and his disciples and the various causes, that led to persecution, and simultaneously persecutions were presented in the perspective of God's salvation.